| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-MRP1/ABCC1 (210-304) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S9MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCC1 |
| Gene ID: |
4363 |
| Uniprot ID: |
MRP1_HUMAN |
| Immunogen Region: |
210-304 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-304 of human MRP1/ABCC1 (NP_004987.2). |
| Immunogen Sequence: |
ESSASFLSRITFWWITGLIV RGYRQPLEGSDLWSLNKEDT SEQVVPVLVKNWKKECAKTR KQPVKVVYSSKDPAQPKESS KVDANEEVEALIVKS |
| Tissue Specificity | Lung, testis and peripheral blood mononuclear cells. |
| Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway. |
| Protein Name | Multidrug Resistance-Associated Protein 1Atp-Binding Cassette Sub-Family C Member 1Glutathione-S-Conjugate-Translocating Atpase Abcc1Leukotriene C(4 TransporterLtc4 Transporter |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-2142691Reactome: R-HSA-382556Reactome: R-HSA-9707564Reactome: R-HSA-9753281Reactome: R-HSA-9758890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Multidrug Resistance-Associated Protein 1 antibodyAnti-Atp-Binding Cassette Sub-Family C Member 1 antibodyAnti-Glutathione-S-Conjugate-Translocating Atpase Abcc1 antibodyAnti-Leukotriene C(4 Transporter antibodyAnti-Ltc4 Transporter antibodyAnti-ABCC1 antibodyAnti-MRP antibodyAnti-MRP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
