| Tissue Specificity | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. |
| Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. |
| Protein Name | Mas-Related G-Protein Coupled Receptor Member X1Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mas-Related G-Protein Coupled Receptor Member X1 antibodyAnti-Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 antibodyAnti-MRGPRX1 antibodyAnti-MRGX1 antibodyAnti-SNSR3 antibodyAnti-SNSR4 antibody |
Information sourced from Uniprot.org
