![Western blot analysis of lysates from wild type (WT) and MPP2 knockout (KO) 293T cells, using [KO Validated] MPP2 Rabbit polyclonal antibody (STJ11100785) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10S.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/89721/358202/STJ11100785_1__60643.1713122522.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and MPP2 knockout (KO) 293T cells, using [KO Validated] MPP2 Rabbit polyclonal antibody (STJ11100785) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10S.")
![Western blot analysis of lysates from wild type (WT) and MPP2 knockout (KO) 293T cells, using [KO Validated] MPP2 Rabbit polyclonal antibody (STJ11100785) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10S.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/89721/358202/STJ11100785_1__60643.1713122522.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and MPP2 knockout (KO) 293T cells, using [KO Validated] MPP2 Rabbit polyclonal antibody (STJ11100785) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10S.")
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MPP2 |
| Gene ID: | 4355 |
| Uniprot ID: | MPP2_HUMAN |
| Immunogen Region: | 1-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human MPP2 (NP_005365.3). |
| Immunogen Sequence: | MPVAATNSETAMQQVLDNLG SLPSATGAAELDLIFLRGIM ESPIVRSLAKAHERLEETKL EAVRDNNLELVQEILRDLAH VAEQSSTAAELAHILQEPHF QSLLETHDSVASKTYETPPP SPGLDPTFSNQPVPPDAVRM VGIRKTAGEHLGVTFRVEGG ELVIARILHGGMVAQQGLLH VGDIIKEVNGQPVGSDPRAL QELLRNASGSVILKILPSYQ EPHLPRQVFV |
| Post Translational Modifications | Phosphorylated by SRC. |
| Function | Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells. |
| Protein Name | Maguk P55 Subfamily Member 2Discs Large Homolog 2Protein Mpp2 |
| Cellular Localisation | CytoplasmCytoskeletonMembraneCell ProjectionDendritePostsynaptic DensityProminently Expressed In The Postsynaptic Densities Of Dendritic SpinesIs Also Detected In Dendritic Shafts |
| Alternative Antibody Names | Anti-Maguk P55 Subfamily Member 2 antibodyAnti-Discs Large Homolog 2 antibodyAnti-Protein Mpp2 antibodyAnti-MPP2 antibodyAnti-DLG2 antibody |
Information sourced from Uniprot.org