Host: |
Rabbit |
Applications: |
WB/ELISA/IHC |
Reactivity: |
Human/Rat/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-U3 small nucleolar ribonucleoprotein protein MPP10 (60-140 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
MPHOSPH10 |
Gene ID: |
10199 |
Uniprot ID: |
MPP10_HUMAN |
Immunogen Region: |
60-140 aa |
Specificity: |
MPP10 Polyclonal Antibody detects endogenous levels of MPP10 protein. |
Immunogen: |
Synthesized peptide derived from MPP10 at the amino acid range 60-140 |
Function | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
Protein Name | U3 Small Nucleolar Ribonucleoprotein Protein Mpp10M Phase Phosphoprotein 10 |
Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
Cellular Localisation | NucleusNucleolusChromosomeFibrillar Region Of The NucleolusAfter Dissolution Of The Nucleolus In Early M Phase Becomes Associated With Chromosomes Through Metaphase And AnaphaseIn Telophase Localized To Small Cellular Prenucleolar Bodies That Not Always Contain FibrillarinThe Reassociation With Nucleolus Is Preceeded By The Arrival Of Fibrillarin |
Alternative Antibody Names | Anti-U3 Small Nucleolar Ribonucleoprotein Protein Mpp10 antibodyAnti-M Phase Phosphoprotein 10 antibodyAnti-MPHOSPH10 antibodyAnti-MPP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance