| Function | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor.NFS1 acting as a sulfur donor for thiocarboxylation reactions. |
| Protein Name | Adenylyltransferase And Sulfurtransferase Mocs3Molybdenum Cofactor Synthesis Protein 3Molybdopterin Synthase SulfurylaseMpt Synthase Sulfurylase Includes - Molybdopterin-Synthase AdenylyltransferaseAdenylyltransferase Mocs3Sulfur Carrier Protein Mocs2a Adenylyltransferase - Molybdopterin-Synthase SulfurtransferaseSulfur Carrier Protein Mocs2a SulfurtransferaseSulfurtransferase Mocs3 |
| Database Links | Reactome: R-HSA-947581 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Adenylyltransferase And Sulfurtransferase Mocs3 antibodyAnti-Molybdenum Cofactor Synthesis Protein 3 antibodyAnti-Molybdopterin Synthase Sulfurylase antibodyAnti-Mpt Synthase Sulfurylase Includes - Molybdopterin-Synthase Adenylyltransferase antibodyAnti-Adenylyltransferase Mocs3 antibodyAnti-Sulfur Carrier Protein Mocs2a Adenylyltransferase - Molybdopterin-Synthase Sulfurtransferase antibodyAnti-Sulfur Carrier Protein Mocs2a Sulfurtransferase antibodyAnti-Sulfurtransferase Mocs3 antibodyAnti-MOCS3 antibodyAnti-UBA4 antibody |
Information sourced from Uniprot.org
