| Tissue Specificity | Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. |
| Protein Name | Matrix Metalloproteinase-16Mmp-16Mmp-X2Membrane-Type Matrix Metalloproteinase 3Mt-Mmp 3Mtmmp3Membrane-Type-3 Matrix MetalloproteinaseMt3-MmpMt3mmp |
| Database Links | Reactome: R-HSA-1592389Reactome: R-HSA-9839383 |
| Cellular Localisation | Isoform Long: Cell MembraneSingle-Pass Type I Membrane ProteinExtracellular SideLocalized At The Cell Surface Of Melanoma CellsIsoform Short: SecretedExtracellular SpaceExtracellular MatrixCell Surface |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-16 antibodyAnti-Mmp-16 antibodyAnti-Mmp-X2 antibodyAnti-Membrane-Type Matrix Metalloproteinase 3 antibodyAnti-Mt-Mmp 3 antibodyAnti-Mtmmp3 antibodyAnti-Membrane-Type-3 Matrix Metalloproteinase antibodyAnti-Mt3-Mmp antibodyAnti-Mt3mmp antibodyAnti-MMP16 antibodyAnti-C8orf57 antibodyAnti-MMPX2 antibody |
Information sourced from Uniprot.org
