Anti-MMP14 antibody [LEM-2/15] (STJA0019076)

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STJA0019076
€473.13 - €2,040.63
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Host: Mouse
Applications: Blocking/ELISA/ICC/IF/FC/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Matrix Metalloproteinase-14 is suitable for use in Universaling, ELISA, Immunocytochemistry, Immunofluorescence, Flow Cytometry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : LEM-2/15
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: MMP14
Gene ID: 4323
Uniprot ID: MMP14_HUMAN
Post Translational Modifications The precursor is cleaved by a furin endopeptidase. Tyrosine phosphorylated by PKDCC/VLK.
Function Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL.
Protein Name Matrix Metalloproteinase-14
Mmp-14
Mmp-X1
Membrane-Type Matrix Metalloproteinase 1
Mt-Mmp 1
Mtmmp1
Membrane-Type-1 Matrix Metalloproteinase
Mt1-Mmp
Mt1mmp
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Reactome: R-HSA-1592389
Reactome: R-HSA-9839383
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Melanosome
Cytoplasm
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Forms A Complex With Bst2 And Localizes To The Cytoplasm
Alternative Antibody Names Anti-Matrix Metalloproteinase-14 antibody
Anti-Mmp-14 antibody
Anti-Mmp-X1 antibody
Anti-Membrane-Type Matrix Metalloproteinase 1 antibody
Anti-Mt-Mmp 1 antibody
Anti-Mtmmp1 antibody
Anti-Membrane-Type-1 Matrix Metalloproteinase antibody
Anti-Mt1-Mmp antibody
Anti-Mt1mmp antibody
Anti-MMP14 antibody

Information sourced from Uniprot.org