Anti-MISP antibody (STJA0007562)

SKU:
STJA0007562
£48.00 - £252.00
Processing The item has been added

Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Mitotic interactor and substrate of PLK1 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MISP
Gene ID: 126353
Uniprot ID: MISP_HUMAN
Specificity: This antibody detects endogenous levels of C19orf21 at Human, Mouse
Immunogen: Synthesized peptide derived from human C19orf21
Function Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.
Protein Name Mitotic Interactor And Substrate Of Plk1
Mitotic Spindle Positioning Protein
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cytoskeleton
Cell Cortex
Predominantly Localizes To Cortical Actin Structures During Interphase And Mitosis
Present In Retraction Fibers
Which Are Formed At Former Adhesion Sites During Mitosis
And At Spicular Membrane Protrusions In Re-Attaching Cytokinetic Cells
Partially Colocalizes With Cytoplasmic F-Actin
Not Detected At Microtubules At Interphase
Nor At Spindle During Mitosis
Alternative Antibody Names Anti-Mitotic Interactor And Substrate Of Plk1 antibody
Anti-Mitotic Spindle Positioning Protein antibody
Anti-MISP antibody
Anti-C19orf21 antibody

Information sourced from Uniprot.org