| Tissue Specificity | Expressed in the cortex and nucleus of the retina lens (at protein level). Major component of lens fiber gap junctions. |
| Post Translational Modifications | Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes. Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma-linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2). |
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens. |
| Protein Name | Lens Fiber Major Intrinsic ProteinAquaporin-0Mip26Mp26 |
| Database Links | Reactome: R-HSA-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionLocalizes To Thin Cell-Cell Junctions In Lens Fiber Cells |
| Alternative Antibody Names | Anti-Lens Fiber Major Intrinsic Protein antibodyAnti-Aquaporin-0 antibodyAnti-Mip26 antibodyAnti-Mp26 antibodyAnti-MIP antibodyAnti-AQP0 antibody |
Information sourced from Uniprot.org
