| Tissue Specificity | Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. |
| Post Translational Modifications | Isoform 2 is degraded by the ubiquitin-proteasome pathway. |
| Function | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. |
| Protein Name | Migration And Invasion-Inhibitory ProteinIgfbp2-Binding ProteinInvasion-Inhibitory Protein 45Iip45 |
| Alternative Antibody Names | Anti-Migration And Invasion-Inhibitory Protein antibodyAnti-Igfbp2-Binding Protein antibodyAnti-Invasion-Inhibitory Protein 45 antibodyAnti-Iip45 antibodyAnti-MIIP antibodyAnti-IIP45 antibody |
Information sourced from Uniprot.org
