| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MIIP (279-388) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MIIP |
| Gene ID: |
60672 |
| Uniprot ID: |
MIIP_HUMAN |
| Immunogen Region: |
279-388 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 279-388 of human MIIP (NP_068752.2). |
| Immunogen Sequence: |
AHVRVSIPLSILEPPHRYHI HRRKSFDASDTLALPRHCLL GWDIFPPKSEKSSAPRNLDL WSSVSAEAQHQKLSGTSSPF HPASPMQMLPPTPTWSVPQV PRPHVPRQKP |
| Tissue Specificity | Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. |
| Post Translational Modifications | Isoform 2 is degraded by the ubiquitin-proteasome pathway. |
| Function | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. |
| Protein Name | Migration And Invasion-Inhibitory ProteinIgfbp2-Binding ProteinInvasion-Inhibitory Protein 45Iip45 |
| Alternative Antibody Names | Anti-Migration And Invasion-Inhibitory Protein antibodyAnti-Igfbp2-Binding Protein antibodyAnti-Invasion-Inhibitory Protein 45 antibodyAnti-Iip45 antibodyAnti-MIIP antibodyAnti-IIP45 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
