• Anti-MHC II DR-alpha + beta chain antibody [Bra30] (STJ16101040)

Anti-MHC II DR-alpha + beta chain antibody [Bra30] (STJ16101040)

SKU:
STJ16101040

€359.38 - €1,655.63
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Host: Mouse
Applications: FC/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MHC II DR-alpha + beta chain is suitable for use in Flow Cytometry and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: Bra30
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunohistology (1-2 µg/ml for 30 min at RT; staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 mi
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Immunogen: A BALB/c mouse was immunized with REH (human ALL cell line). Fusion partner: SP-2/0.
Background MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an Alpha and Beta chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and-DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

Information sourced from Uniprot.org