| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MFGE8 |
| Gene ID: | 4240 |
| Uniprot ID: | MFGM_HUMAN |
| Immunogen Region: | 231-387 |
| Specificity: | Recombinant Protein corresponding to a sequence within amino acids 231-387 of human MFGE8 (NP_005919.2). |
| Immunogen Sequence: | ANPLGLKNNSIPDKQITASS SYKTWGLHLFSWNPSYARLD KQGNFNAWVAGSYGNDQWLQ VDLGSSKEVTGIITQGARNF GSVQFVASYKVAYSNDSANW TEYQDPRTGSSKIFPGNWDN HSHKKNLFETPILARYVRIL PVAWHNRIALRLELLGC |
| Tissue Specificity | Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. |
| Post Translational Modifications | Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273. |
| Function | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin: Main constituent of aortic medial amyloid. |
| Protein Name | Lactadherin Breast Epithelial Antigen Ba46 Hmfg Mfgm Milk Fat Globule-Egf Factor 8 Mfg-E8 Sed1 Cleaved Into - Lactadherin Short Form - Medin |
| Database Links | Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-977225 |
| Cellular Localisation | Membrane Peripheral Membrane Protein Secreted Cytoplasmic Vesicle Secretory Vesicle Acrosome Membrane Located In The Acrosomal Region Of Zona-Pellucida Bound Sperm |
| Alternative Antibody Names | Anti-Lactadherin antibody Anti-Breast Epithelial Antigen Ba46 antibody Anti-Hmfg antibody Anti-Mfgm antibody Anti-Milk Fat Globule-Egf Factor 8 antibody Anti-Mfg-E8 antibody Anti-Sed1 Cleaved Into - Lactadherin Short Form - Medin antibody Anti-MFGE8 antibody |
Information sourced from Uniprot.org