| Host: |
Mouse |
| Applications: |
FC/IHC-F/IHC-P/IF/WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-MFG-E8/Lactadherin/p47 is suitable for use in Flow Cytometry, Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
MFG-06 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1K |
| Formulation: |
PBS with 0.02% sodium azide |
| Concentration: |
100 ug/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
MFGE8 |
| Gene ID: |
4240 |
| Uniprot ID: |
MFGM_HUMAN |
| Immunogen: |
milk fat globule membrane preparation derived from human breast cancer cell line PMC42 |
| Tissue Specificity | Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. |
| Post Translational Modifications | Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273. |
| Function | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin: Main constituent of aortic medial amyloid. |
| Protein Name | LactadherinBreast Epithelial Antigen Ba46HmfgMfgmMilk Fat Globule-Egf Factor 8Mfg-E8Sed1 Cleaved Into - Lactadherin Short Form - Medin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-977225 |
| Cellular Localisation | MembranePeripheral Membrane ProteinSecretedCytoplasmic VesicleSecretory VesicleAcrosome MembraneLocated In The Acrosomal Region Of Zona-Pellucida Bound Sperm |
| Alternative Antibody Names | Anti-Lactadherin antibodyAnti-Breast Epithelial Antigen Ba46 antibodyAnti-Hmfg antibodyAnti-Mfgm antibodyAnti-Milk Fat Globule-Egf Factor 8 antibodyAnti-Mfg-E8 antibodyAnti-Sed1 Cleaved Into - Lactadherin Short Form - Medin antibodyAnti-MFGE8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
