| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNA-binding E3 ubiquitin-protein ligase MEX3C is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MEX3C |
| Gene ID: |
51320 |
| Uniprot ID: |
MEX3C_HUMAN |
| Specificity: |
This antibody detects endogenous levels of MEX3C at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human MEX3C |
| Function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. |
| Protein Name | Rna-Binding E3 Ubiquitin-Protein Ligase Mex3cRing Finger And Kh Domain-Containing Protein 2Ring Finger Protein 194Ring-Type E3 Ubiquitin Transferase Mex3c |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusPredominantly Expressed In The Cytoplasm And Shuttles Between The Cytoplasm And The Nucleus Through The Crm1 Export PathwayMay Act As Suppressor Of Replication Stress And Chromosome Missegregation |
| Alternative Antibody Names | Anti-Rna-Binding E3 Ubiquitin-Protein Ligase Mex3c antibodyAnti-Ring Finger And Kh Domain-Containing Protein 2 antibodyAnti-Ring Finger Protein 194 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mex3c antibodyAnti-MEX3C antibodyAnti-RKHD2 antibodyAnti-RNF194 antibodyAnti-BM-013 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
