| Function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. |
| Protein Name | Rna-Binding E3 Ubiquitin-Protein Ligase Mex3cRing Finger And Kh Domain-Containing Protein 2Ring Finger Protein 194Ring-Type E3 Ubiquitin Transferase Mex3c |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusPredominantly Expressed In The Cytoplasm And Shuttles Between The Cytoplasm And The Nucleus Through The Crm1 Export PathwayMay Act As Suppressor Of Replication Stress And Chromosome Missegregation |
| Alternative Antibody Names | Anti-Rna-Binding E3 Ubiquitin-Protein Ligase Mex3c antibodyAnti-Ring Finger And Kh Domain-Containing Protein 2 antibodyAnti-Ring Finger Protein 194 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mex3c antibodyAnti-MEX3C antibodyAnti-RKHD2 antibodyAnti-RNF194 antibodyAnti-BM-013 antibody |
Information sourced from Uniprot.org
