| Function | Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain. N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite. May also mediate N(3)-methylcytidine modification of mRNAs. The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo. |
| Protein Name | Trna N(3-Cytidine Methyltransferase Mettl8 - MitochondrialMethyltransferase-Like Protein 8Mrna N(3-Methylcytidine Methyltransferase Mettl8 |
| Cellular Localisation | MitochondrionMitochondrial Protein: The Cytoplasmic Or Nuclear Localization Observed By Some Groups Is Either The Result Of An Incorrect Localization Caused By N-Terminal Tagging That Interferes With Mitochondrial TargetingOr Splice Isoforms That Lack The N-Terminal Mitochondrial Transit Sequence |
| Alternative Antibody Names | Anti-Trna N(3-Cytidine Methyltransferase Mettl8 - Mitochondrial antibodyAnti-Methyltransferase-Like Protein 8 antibodyAnti-Mrna N(3-Methylcytidine Methyltransferase Mettl8 antibodyAnti-METTL8 antibody |
Information sourced from Uniprot.org
