| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMT1A |
| Gene ID: |
25840 |
| Uniprot ID: |
TMT1A_HUMAN |
| Immunogen Region: |
30-244 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-244 of human METTL7A (NP_054752.3). |
| Immunogen Sequence: |
WICKKWFPYFLVRFTVIYNE QMASKKRELFSNLQEFAGPS GKLSLLEVGCGTGANFKFYP PGCRVTCIDPNPNFEKFLIK SIAENRHLQFERFVVAAGEN MHQVADGSVDVVVCTLVLCS VKNQERILREVCRVLRPGGA FYFMEHVAAECSTWNYFWQQ VLDPAWHLLFDGCNLTRESW KALERASFSKLKLQHIQAPL SWELVRPHIYGYAVK |
| Tissue Specificity | Expressed in the liver. |
| Post Translational Modifications | Methylated at lysine residues most likely by EZH2. |
| Function | Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface. Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival. Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles. (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. |
| Protein Name | Thiol S-Methyltransferase Tmt1aMethyltransferase-Like Protein 7aN6-Adenosine-Methyltransferase Tmt1aProtein Aam-BThiol Methyltransferase 1a |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Lipid DropletEndoplasmic ReticulumMembraneMicrosomeCytoplasmCytosolInserted In The Er Membrane And Migrates From The Inserted Site To Lipid Droplet |
| Alternative Antibody Names | Anti-Thiol S-Methyltransferase Tmt1a antibodyAnti-Methyltransferase-Like Protein 7a antibodyAnti-N6-Adenosine-Methyltransferase Tmt1a antibodyAnti-Protein Aam-B antibodyAnti-Thiol Methyltransferase 1a antibodyAnti-TMT1A antibodyAnti-METTL7A antibodyAnti-PRO0066 antibodyAnti-UNQ1902 antibodyAnti-PRO4348 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
