Anti-MEKK2 antibody (1-100) [S4MR] (STJ11103104)

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STJ11103104
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S4MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAP3K2
Gene ID: 10746
Uniprot ID: M3K2_HUMAN
Immunogen Region: 1-100
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEKK2 (Q9Y2U5).
Immunogen Sequence: MDDQQALNSIMQDLAVLHKA SRPALSLQETRKAKSSSPKK QNDVRVKFEHRGEKRILQFP RPVKLEDLRSKAKIAFGQSM DLHYTNNELVIPLTTQDDLD
Post Translational Modifications Autophosphorylated. Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation.
Function Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase 2
Mapk/Erk Kinase Kinase 2
Mek Kinase 2
Mekk 2
Cellular Localisation Cytoplasm
Nucleus
Upon Egf Stimulation
Translocates Into The Nucleus
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase 2 antibody
Anti-Mapk/Erk Kinase Kinase 2 antibody
Anti-Mek Kinase 2 antibody
Anti-Mekk 2 antibody
Anti-MAP3K2 antibody
Anti-MAPKKK2 antibody
Anti-MEKK2 antibody

Information sourced from Uniprot.org