| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP3K2 |
| Gene ID: | 10746 |
| Uniprot ID: | M3K2_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEKK2 (Q9Y2U5). |
| Immunogen Sequence: | MDDQQALNSIMQDLAVLHKA SRPALSLQETRKAKSSSPKK QNDVRVKFEHRGEKRILQFP RPVKLEDLRSKAKIAFGQSM DLHYTNNELVIPLTTQDDLD |
| Post Translational Modifications | Autophosphorylated. Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. |
| Function | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 2Mapk/Erk Kinase Kinase 2Mek Kinase 2Mekk 2 |
| Cellular Localisation | CytoplasmNucleusUpon Egf StimulationTranslocates Into The Nucleus |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 2 antibodyAnti-Mapk/Erk Kinase Kinase 2 antibodyAnti-Mek Kinase 2 antibodyAnti-Mekk 2 antibodyAnti-MAP3K2 antibodyAnti-MAPKKK2 antibodyAnti-MEKK2 antibody |
Information sourced from Uniprot.org