Name: Anti-MDM4 nanobody [SAA1189] (STJN000040)
SKU: STJN000040
Availability: InStock

Anti-MDM4 nanobody [SAA1189] (STJN000040)

SKU:

STJN000040

£195.50 - £1,319.50

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Short Description :	Alpaca monoclonal nanobody anti-Protein Mdm4 is suitable for use in ELISA research applications.
Applications:	ELISA
Host:	Alpaca
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality :	Monoclonal
Clone ID :	SAA1189
Isotype:	VHH-8His-Cys-tag
Conjugation:	Unconjugated
Concentration:	1 mg/mL
Purification:	Purified by Nickel column.
Formulation:	0.01M PBS, pH 7.4.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.

Post Translational Modifications	Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent. Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein.
Function	Along with MDM2, contributes to TP53 regulation. Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Protein Name	Protein Mdm4 Double Minute 4 Protein Mdm2-Like P53-Binding Protein Protein Mdmx P53-Binding Protein Mdm4
Database Links	Reactome: R-HSA-2559580 Reactome: R-HSA-2559585 Reactome: R-HSA-5689880 Reactome: R-HSA-6804756 Reactome: R-HSA-6804757 Reactome: R-HSA-6804760 Reactome: R-HSA-69541
Cellular Localisation	Nucleus
Alternative Nanobody Names	Anti-Protein Mdm4 nanobody Anti-Double Minute 4 Protein nanobody Anti-Mdm2-Like P53-Binding Protein nanobody Anti-Protein Mdmx nanobody Anti-P53-Binding Protein Mdm4 nanobody Anti-MDM4 nanobody Anti-MDMX nanobody

Information sourced from Uniprot.org

Model	Name	Host	Clonality	Reactivity	Application
STJ98235	Anti-MDM4 antibody [2D10F4] (STJ98235)	Mouse	Monoclonal	Human	WB/IHC/IF/ELISA
STJ94058	Anti-MDM4 antibody (336-385 aa) (STJ94058)	Rabbit	Polyclonal	Human/Mouse/Rat	WB/IHC/IF/ELISA
STJN000008	Anti-CFTR nanobody [SAA0794] (STJN000008)	Alpaca	Monoclonal	Human	ELISA/FC
STJN000010	Anti-MC4R nanobody [SAA0796] (STJN000010)	Alpaca	Monoclonal	Human	Blocking/ELISA/FC
STJN000011	Anti-PTH1R nanobody [SAA0797] (STJN000011)	Alpaca	Monoclonal	Human	ELISA/RIA

Anti-MDM4 nanobody [SAA1189] (STJN000040)

General Information