| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Mapk-regulated corepressor-interacting protein 1 (14-64 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MCRIP1 |
| Gene ID: | 348262 |
| Uniprot ID: | MCRI1_HUMAN |
| Immunogen Region: | 14-64 aa |
| Specificity: | This antibody detects endogenous levels of F195B at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human F195B at the amino acid range 14-64 |
| Function | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. |
| Protein Name | Mapk-Regulated Corepressor-Interacting Protein 1Granulin-2Protein Fam195b |
| Cellular Localisation | NucleusCytoplasmStress Granule |
| Alternative Antibody Names | Anti-Mapk-Regulated Corepressor-Interacting Protein 1 antibodyAnti-Granulin-2 antibodyAnti-Protein Fam195b antibodyAnti-MCRIP1 antibodyAnti-FAM195B antibodyAnti-GRAN2 antibody |
Information sourced from Uniprot.org