| Function | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel. |
| Protein Name | Mucolipin-2Transient Receptor Potential Channel Mucolipin 2Trpml2 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLate Endosome MembraneLysosome MembraneRecycling Endosome MembraneLocalizes To Recycling Endosomes In Activated Macrophages And Microglia |
| Alternative Antibody Names | Anti-Mucolipin-2 antibodyAnti-Transient Receptor Potential Channel Mucolipin 2 antibodyAnti-Trpml2 antibodyAnti-MCOLN2 antibody |
Information sourced from Uniprot.org
