| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MCMBP |
| Gene ID: | 79892 |
| Uniprot ID: | MCMBP_HUMAN |
| Immunogen Region: | 1-240 |
| Immunogen Sequence: | MPCGEDWLSHPLGIVQGFFA QNGVNPDWEKKVIEYFKEKL KENNAPKWVPSLNEVPLHYL KPNSFVKFRCMIQDMFDPEF YMGVYETVNQNTKAHVLHFG KYRDVAECGPQQELDLNSPR NTTLERQTFYCVPVPGESTW VKEAYVNANQARVSPSTSYT PSRHKRSYEDDDDMDLQPNK QKDQHAGARQAGSVGGLQWC GEPKRLETEASTGQQLNSLN LSSPFDLNFPLPGEKGPAC |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MCMBP (NP_079110.1). |
| Function | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP.probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. |
| Protein Name | Mini-Chromosome Maintenance Complex-Binding ProteinMcm-BpMcm-Binding Protein |
| Database Links | |
| Cellular Localisation | NucleusAssociates With ChromatinHighly Associated With Chromatin In G1/S And S PhasesReduced Binding To Chromatin In G2And Further Decreased Binding In Early M PhaseIt Then Reassociates With Chromatin In Late M PhaseDissociates From Chromatin Later Than Component Of The Mcm Complex |
| Alternative Antibody Names | Anti-Mini-Chromosome Maintenance Complex-Binding Protein antibodyAnti-Mcm-Bp antibodyAnti-Mcm-Binding Protein antibodyAnti-MCMBP antibodyAnti-C10orf119 antibody |
Information sourced from Uniprot.org
