Anti-MC4R nanobody [SAA0796] (STJN000010)

Anti-MC4R nanobody [SAA0796] (STJN000010)

SKU:
STJN000010
£209.50 - £1,333.50
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: Blocking/ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Melanocortin Receptor 4 is suitable for use in Universaling, ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0796
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: MC4R
Gene ID: 4160
Uniprot ID: MC4R_HUMAN
Function Hormone receptor that acts as a key component of the leptin-melanocortin pathway at the intersection of homeostatic maintenance of energetic state. Plays a role in regulating food intake: activation by a stimulating hormone such as anorexigenic alpha-melanocyte stimulating hormone (alpha-MSH) inhibits appetite, whereas binding to a natural antagonist like Agouti-related protein/AGRP promotes appetite. G-protein-coupled receptor that activates conventional Galphas signaling leading to induction of anorexogenic signaling in the hypothalamus to result in negative energy balance. Regulates the firing activity of neurons from the hypothalamus by alpha-MSH and AGRP independently of Galphas signaling by ligand-induced coupling of closure of inwardly rectifying potassium channel KCNJ13. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via nesfatin-1/NUCB2 leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion in the intestinal epithelium.
Protein Name Melanocortin Receptor 4
Mc4-R
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418555
Reactome: R-HSA-9856649
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Nanobody Names Anti-Melanocortin Receptor 4 nanobody
Anti-Mc4-R nanobody
Anti-MC4R nanobody

Information sourced from Uniprot.org

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