| Function | Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression. |
| Protein Name | Membrane-Bound Transcription Factor Site-2 ProteaseEndopeptidase S2pSterol Regulatory Element-Binding Proteins Intramembrane ProteaseSrebps Intramembrane Protease |
| Database Links | Reactome: R-HSA-1655829Reactome: R-HSA-381033Reactome: R-HSA-8874177Reactome: R-HSA-8874211Reactome: R-HSA-8963889 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Membrane-Bound Transcription Factor Site-2 Protease antibodyAnti-Endopeptidase S2p antibodyAnti-Sterol Regulatory Element-Binding Proteins Intramembrane Protease antibodyAnti-Srebps Intramembrane Protease antibodyAnti-MBTPS2 antibodyAnti-S2P antibody |
Information sourced from Uniprot.org
