| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. |
| Protein Name | Muscleblind-Like Protein 3Cys3his Ccg1-Required ProteinMuscleblind-Like X-Linked ProteinProtein Hchcr |
| Cellular Localisation | NucleusCytoplasmGreater Concentration In The NucleusIn Both Dm1 And Dm2 PatientsColocalizes With Nuclear Foci Of Retained Expanded-Repeat Transcripts |
| Alternative Antibody Names | Anti-Muscleblind-Like Protein 3 antibodyAnti-Cys3his Ccg1-Required Protein antibodyAnti-Muscleblind-Like X-Linked Protein antibodyAnti-Protein Hchcr antibodyAnti-MBNL3 antibodyAnti-CHCR antibodyAnti-MBLX39 antibodyAnti-MBXL antibody |
Information sourced from Uniprot.org
