• Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
  • Western blot analysis of mouse-kidney cells using Antibody diluted at 500. Secondary antibody was diluted at 1:20000

Anti-MBL2 antibody (21-70 aa) (STJ98651)

SKU:
STJ98651

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Mannose-binding protein C (21-70 aa) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MBL2
Gene ID: 4153
Uniprot ID: MBL2_HUMAN
Immunogen Region: 21-70 aa
Specificity: The antibody detects endogenous MBL-C protein
Immunogen: Synthetic peptide from the human protein at the amino acid range 21-70
Function Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response.
Protein Name Mannose-Binding Protein C
Mbp-C
Collectin-1
Mbp1
Mannan-Binding Protein
Mannose-Binding Lectin
Database Links Reactome: R-HSA-166662
Reactome: R-HSA-166663
Reactome: R-HSA-9705671
Cellular Localisation Secreted
Alternative Antibody Names Anti-Mannose-Binding Protein C antibody
Anti-Mbp-C antibody
Anti-Collectin-1 antibody
Anti-Mbp1 antibody
Anti-Mannan-Binding Protein antibody
Anti-Mannose-Binding Lectin antibody
Anti-MBL2 antibody
Anti-COLEC1 antibody
Anti-MBL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance