| Tissue Specificity | Highly expressed in brain, heart, kidney, stomach, testis and placenta. |
| Function | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases to chromatin. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as a transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 2DemethylaseDmtaseMethyl-Cpg-Binding Protein Mbd2 |
| Database Links | Reactome: R-HSA-427413Reactome: R-HSA-73728 |
| Cellular Localisation | NucleusChromosomeNuclearIn Discrete FociDetected At Replication Foci In Late S PhaseLocalizes To Methylated ChromatinLocalizes To Sites Of Dna Damage In A Manner Partially Dependent On Zmynd8 |
| Alternative Antibody Names | Anti-Methyl-Cpg-Binding Domain Protein 2 antibodyAnti-Demethylase antibodyAnti-Dmtase antibodyAnti-Methyl-Cpg-Binding Protein Mbd2 antibodyAnti-MBD2 antibody |
Information sourced from Uniprot.org
