Anti-MAX antibody (C-Term) (STJ70025)

SKU:
STJ70025-100
€390.63
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Host: Goat
Applications: Pep-ELISA/WB/IF/IHC
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-MAX (C-Term) is suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:32000.
WB: Approx 22kDa band observed in lysates of cell line Jurkat (calculated MW of 18.3kDa according to NP_002373.3). Recommended concentration: 0.01-0.03µg/ml. Primary incubation 1 hour at r
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: MAX
Gene ID: 4149
Uniprot ID: MAX_HUMAN
Immunogen Region: C-Term
Accession Number: NP_002373.3; NP_660087.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_002373.3; NP_660087.1).
Immunogen Sequence: EEPQSRKKLRMEAS
Post Translational Modifications Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
Function Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CACGATG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Protein Name Protein Max
Class D Basic Helix-Loop-Helix Protein 4
Bhlhd4
Myc-Associated Factor X
Database Links Reactome: R-HSA-1362277
Reactome: R-HSA-69202
Reactome: R-HSA-69656
Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Cell Projection
Dendrite
Alternative Antibody Names Anti-Protein Max antibody
Anti-Class D Basic Helix-Loop-Helix Protein 4 antibody
Anti-Bhlhd4 antibody
Anti-Myc-Associated Factor X antibody
Anti-MAX antibody
Anti-BHLHD4 antibody

Information sourced from Uniprot.org