Anti-MAX antibody (C-Term) (STJ70025)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-MAX (C-Term) is suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IF/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 22kDa band observed in lysates of cell line Jurkat (calculated MW of 18.3kDa according to NP_002373.3). Recommended concentration: 0.01-0.03µg/ml. Primary incubation 1 hour at r |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MAX |
| Gene ID | 4149 |
| Uniprot ID | MAX_HUMAN |
| Accession Number | NP_002373.3; NP_660087.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | EEPQSRKKLRMEAS |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_002373.3; NP_660087.1). |
Additional Info
| Post Translational Modifications | Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes. |
| Function | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CACGATG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. |
| Protein Name | Protein MaxClass D Basic Helix-Loop-Helix Protein 4Bhlhd4Myc-Associated Factor X |
| Database Links | Reactome: R-HSA-1362277Reactome: R-HSA-69202Reactome: R-HSA-69656Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Protein Max antibodyAnti-Class D Basic Helix-Loop-Helix Protein 4 antibodyAnti-Bhlhd4 antibodyAnti-Myc-Associated Factor X antibodyAnti-MAX antibodyAnti-BHLHD4 antibody |
Information sourced from Uniprot.org