Anti-Mast Cell Tryptase antibody [7C4-3H6-1E9] (STJA0033466)

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STJA0033466
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-Mast Cell Tryptase for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : 7C4-3H6-1E9
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification: Affinity Chromatography
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:500
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: TPSAB1
Gene ID: 7177
Uniprot ID: TRYB1_HUMAN
Immunogen: Synthesized peptide derived from human Mast cell tryptase
Tissue Specificity Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin.in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
Protein Name Tryptase Alpha/Beta-1
Tryptase-1
Tryptase I
Tryptase Alpha-1
Database Links Reactome: R-HSA-1592389
Cellular Localisation Secreted
Released From The Secretory Granules Upon Mast Cell Activation
Alternative Antibody Names Anti-Tryptase Alpha/Beta-1 antibody
Anti-Tryptase-1 antibody
Anti-Tryptase I antibody
Anti-Tryptase Alpha-1 antibody
Anti-TPSAB1 antibody
Anti-TPS1 antibody
Anti-TPS2 antibody
Anti-TPSB1 antibody

Information sourced from Uniprot.org

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