| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity. |
| Function | Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1. |
| Protein Name | Map/Microtubule Affinity-Regulating Kinase 3C-Tak1Ctak1Cdc25c-Associated Protein Kinase 1Elkl Motif Kinase 2Emk-2Protein Kinase Stk10Ser/Thr Protein Kinase Par-1Par-1aSerine/Threonine-Protein Kinase P78 |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell ProjectionDendriteCytoplasm |
| Alternative Antibody Names | Anti-Map/Microtubule Affinity-Regulating Kinase 3 antibodyAnti-C-Tak1 antibodyAnti-Ctak1 antibodyAnti-Cdc25c-Associated Protein Kinase 1 antibodyAnti-Elkl Motif Kinase 2 antibodyAnti-Emk-2 antibodyAnti-Protein Kinase Stk10 antibodyAnti-Ser/Thr Protein Kinase Par-1 antibodyAnti-Par-1a antibodyAnti-Serine/Threonine-Protein Kinase P78 antibodyAnti-MARK3 antibodyAnti-CTAK1 antibodyAnti-EMK2 antibody |
Information sourced from Uniprot.org
