| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Marcks-Related Protein (95-195) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MARCKSL1 |
| Gene ID: |
65108 |
| Uniprot ID: |
MRP_HUMAN |
| Immunogen Region: |
95-195 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 95-195 of human MARCKSL1 (NP_075385.1). |
| Immunogen Sequence: |
KKPFKLSGLSFKRNRKEGGG DSSASSPTEEEQEQGEIGAC SDEGTAQEGKAAATPESQEP QAKGAEASAASEEEAGPQAT EPSTPSGPESGPTPASAEQN E |
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin. |
| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. |
| Protein Name | Marcks-Related ProteinMarcks-Like Protein 1Macrophage Myristoylated Alanine-Rich C Kinase SubstrateMac-MarcksMacmarcks |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneLipid-AnchorAssociates With The Membrane Via The Insertion Of The N-Terminal N-Myristoyl Chain And The Partial Insertion Of The Effector DomainAssociation Of The Effector Domain With Membranes May Be Regulated By Ca(2+)/CalmodulinColocalizes With F-Actin At The Leading Edge Of Migrating CellsIn Prostate CancersShows Strong Expression At Apical And/Or Basal Regions Of The Cell And Also Has Weak Cytoplasmic Expression |
| Alternative Antibody Names | Anti-Marcks-Related Protein antibodyAnti-Marcks-Like Protein 1 antibodyAnti-Macrophage Myristoylated Alanine-Rich C Kinase Substrate antibodyAnti-Mac-Marcks antibodyAnti-Macmarcks antibodyAnti-MARCKSL1 antibodyAnti-MLP antibodyAnti-MRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
