| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Dual specificity mitogen-activated protein kinase kinase 5 is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP2K5 |
| Gene ID: | 5607 |
| Uniprot ID: | MP2K5_HUMAN |
| Specificity: | This antibody detects endogenous levels of MEK5 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the human MEK5 |
| Post Translational Modifications | Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 Map Kinase Kinase 5 Mapkk 5 Mapk/Erk Kinase 5 Mek 5 |
| Database Links | Reactome: R-HSA-198765 |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 antibody Anti-Map Kinase Kinase 5 antibody Anti-Mapkk 5 antibody Anti-Mapk/Erk Kinase 5 antibody Anti-Mek 5 antibody Anti-MAP2K5 antibody Anti-MEK5 antibody Anti-MKK5 antibody Anti-PRKMK5 antibody |
Information sourced from Uniprot.org