| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Dual specificity mitogen-activated protein kinase kinase 2 is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 2C3 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP2K2 |
| Gene ID: | 5605 |
| Uniprot ID: | MP2K2_HUMAN |
| Specificity: | MEK2 protein detects endogenous levels of MEK2 |
| Immunogen: | Synthesized peptide derived from the human MEK-2 around the non-phosphorylation site of T394. |
| Function | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner.by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 Map Kinase Kinase 2 Mapkk 2 Erk Activator Kinase 2 Mapk/Erk Kinase 2 Mek 2 |
| Database Links | Reactome: R-HSA-112411 Reactome: R-HSA-170968 Reactome: R-HSA-445144 Reactome: R-HSA-5210891 Reactome: R-HSA-5673000 Reactome: R-HSA-5674135 Reactome: R-HSA-5674499 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9652169 Reactome: R-HSA-9656223 |
| Cellular Localisation | Cytoplasm Membrane Peripheral Membrane Protein Membrane Localization Is Probably Regulated By Its Interaction With Ksr1 |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 antibody Anti-Map Kinase Kinase 2 antibody Anti-Mapkk 2 antibody Anti-Erk Activator Kinase 2 antibody Anti-Mapk/Erk Kinase 2 antibody Anti-Mek 2 antibody Anti-MAP2K2 antibody Anti-MEK2 antibody Anti-MKK2 antibody Anti-PRKMK2 antibody |
Information sourced from Uniprot.org