| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAML1 |
| Gene ID: | 9794 |
| Uniprot ID: | MAML1_HUMAN |
| Immunogen Region: | 1-300 |
| Immunogen Sequence: | MVLPTCPMAEFALPRHSAVM ERLRRRIELCRRHHSTCEAR YEAVSPERLELERQHTFALH QRCIQAKAKRAGKHRQPPAA TAPAPAAPAPRLDAADGPEH GRPATHLHDTVKRNLDSATS PQNGDQQNGYGDLFPGHKKT RREAPLGVAISSNGLPPASP LGQSDKPSGADALQSSGKHS LGLDSLNKKRLADSSLHLNG GSNPSESFPLSLNKELKQEP VEDLPCMITGTVGSISQSN |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MAML1 (NP_055572.1). |
| Tissue Specificity | Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. |
| Function | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. |
| Protein Name | Mastermind-Like Protein 1Mam-1 |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2197563Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-350054Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9793380 |
| Cellular Localisation | Nucleus SpeckleNuclearIn A Punctate Manner |
| Alternative Antibody Names | Anti-Mastermind-Like Protein 1 antibodyAnti-Mam-1 antibodyAnti-MAML1 antibodyAnti-KIAA0200 antibody |
Information sourced from Uniprot.org
