Anti-MALT1 antibody [EBS-T-007] (STJ16101077)

Anti-MALT1 antibody [EBS-T-007] (STJ16101077)

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STJ16101077
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Host: Mouse
Applications: WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-MALT1 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : EBS-T-007
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: Immunoblotting (1-2 µg/ml). Immunohistology (formalin-fixed: 1-2 µg/ml for 30 min at RT; requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min. followed by cooling at RT for 20 min).
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: MALT1
Gene ID: 10892
Uniprot ID: MALT1_HUMAN
Immunogen: A BALB/c mouse was immunized with human MALT1 recombinant protein. Fusion partner: Sp2/0.
Tissue Specificity Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
Function Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.
Protein Name Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1
Malt Lymphoma-Associated Translocation
Paracaspase
Database Links Reactome: R-HSA-1169091
Reactome: R-HSA-202424
Reactome: R-HSA-2871837
Reactome: R-HSA-5607764
Reactome: R-HSA-5660668
Cellular Localisation Cytoplasm
Perinuclear Region
Nucleus
Shuttles Between The Nucleus And Cytoplasm
Found In Perinuclear Structures Together With Bcl10
Alternative Antibody Names Anti-Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 antibody
Anti-Malt Lymphoma-Associated Translocation antibody
Anti-Paracaspase antibody
Anti-MALT1 antibody
Anti-MLT antibody

Information sourced from Uniprot.org

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