Anti-MAK antibody (370-435) (STJ119600)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAK (370-435) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAK |
| Gene ID | 4117 |
| Uniprot ID | MAK_HUMAN |
| Immunogen Region | 370-435 |
| Immunogen Sequence | TLFPSIVKNMPTKPNGTLSH KSGRRRWGQTIFKSGDSWEE LEDYDFGASHSKKPSMGVFK EKRKKD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 370-435 of human MAK (NP_005897.1). |
Additional Info
| Tissue Specificity | Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated on serine and threonine residues. |
| Function | Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. |
| Protein Name | Serine/Threonine-Protein Kinase MakMale Germ Cell-Associated Kinase |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleMidbodyCell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Inner SegmentLocalized In Both The Connecting Cilia And The Outer Segment AxonemesLocalized Uniformly In Nuclei During InterphaseTo The Mitotic Spindle And Centrosomes During Metaphase And AnaphaseAnd Also To Midbody At Anaphase Until Telophase |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Mak antibodyAnti-Male Germ Cell-Associated Kinase antibodyAnti-MAK antibody |
Information sourced from Uniprot.org