| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAK |
| Gene ID: | 4117 |
| Uniprot ID: | MAK_HUMAN |
| Immunogen Region: | 370-435 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 370-435 of human MAK (NP_005897.1). |
| Immunogen Sequence: | TLFPSIVKNMPTKPNGTLSH KSGRRRWGQTIFKSGDSWEE LEDYDFGASHSKKPSMGVFK EKRKKD |
| Tissue Specificity | Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated on serine and threonine residues. |
| Function | Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. |
| Protein Name | Serine/Threonine-Protein Kinase Mak Male Germ Cell-Associated Kinase |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Spindle Midbody Cell Projection Cilium Photoreceptor Outer Segment Photoreceptor Inner Segment Localized In Both The Connecting Cilia And The Outer Segment Axonemes Localized Uniformly In Nuclei During Interphase To The Mitotic Spindle And Centrosomes During Metaphase And Anaphase And Also To Midbody At Anaphase Until Telophase |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Mak antibody Anti-Male Germ Cell-Associated Kinase antibody Anti-MAK antibody |
Information sourced from Uniprot.org