| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAFA |
| Gene ID: | 389692 |
| Uniprot ID: | MAFA_HUMAN |
| Immunogen Region: | 269-353 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-353 of human MAFA (NP_963883.2). |
| Immunogen Sequence: | QSCRFKRVQQRHILESEKCQ LQSQVEQLKLEVGRLAKERD LYKEKYEKLAGRGGPGSAGG AGFPREPSPPQAGPGGAKGT ADFFL |
| Tissue Specificity | Expressed in the islets of Langerhans (at protein level). |
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Phosphorylated at tyrosines. |
| Function | Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence. |
| Protein Name | Transcription Factor MafaPancreatic Beta-Cell-Specific Transcriptional ActivatorRipe3b1 FactorV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A |
| Database Links | Reactome: R-HSA-210745 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Mafa antibodyAnti-Pancreatic Beta-Cell-Specific Transcriptional Activator antibodyAnti-Ripe3b1 Factor antibodyAnti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A antibodyAnti-MAFA antibody |
Information sourced from Uniprot.org