| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LYPLA1 (1-230) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LYPLA1 |
| Gene ID: |
10434 |
| Uniprot ID: |
LYPA1_HUMAN |
| Immunogen Region: |
1-230 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human LYPLA1 (NP_006321.1). |
| Immunogen Sequence: |
MCGNNMSTPLPAIVPAARKA TAAVIFLHGLGDTGHGWAEA FAGIRSSHIKYICPHAPVRP VTLNMNVAMPSWFDIIGLSP DSQEDESGIKQAAENIKALI DQEVKNGIPSNRIILGGFSQ GGALSLYTALTTQQKLAGVT ALSCWLPLRASFPQGPIGGA NRDISILQCHGDCDPLVPLM FGSLTVEKLKTLVNPANVTF KTYEGMMHSSCQQEMMDVKQ FIDKLLPPID |
| Tissue Specificity | Platelets. |
| Function | Acts as a acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Could also depalmitoylate ADRB2. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA. |
| Protein Name | Acyl-Protein Thioesterase 1Apt-1Hapt1Lysophospholipase 1Lysophospholipase ILpl-ILysopla IPalmitoyl-Protein Hydrolase |
| Database Links | Reactome: R-HSA-203615Reactome: R-HSA-9648002 |
| Cellular Localisation | CytoplasmCell MembraneNucleus MembraneEndoplasmic ReticulumShows Predominantly A Cytoplasmic Localization With A Weak Expression In The Cell MembraneNuclear Membrane And Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Acyl-Protein Thioesterase 1 antibodyAnti-Apt-1 antibodyAnti-Hapt1 antibodyAnti-Lysophospholipase 1 antibodyAnti-Lysophospholipase I antibodyAnti-Lpl-I antibodyAnti-Lysopla I antibodyAnti-Palmitoyl-Protein Hydrolase antibodyAnti-LYPLA1 antibodyAnti-APT1 antibodyAnti-LPL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
