| Tissue Specificity | Predominantly expressed in testis. |
| Function | Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal. |
| Protein Name | Cell Growth-Regulating Nucleolar Protein |
| Database Links | |
| Cellular Localisation | NucleusNucleolusCytoplasmCell ProjectionCiliumPhotoreceptor Outer SegmentComponent Of Pre-Ribosomal ParticlesIncluding Pre-40sPre-60s And Pre-90sAssociated With Cytoplasmic RibosomesBut Not PolysomesAs A Component Of The 60s SubunitIn The RetinaPredominantly Expressed In Photoreceptor Outer SegmentsIn The NucleolusColocalizes With Nucleolin/NclTherefore May Reside In The Dense Fibrillar Component (Dfc) |
| Alternative Antibody Names | Anti-Cell Growth-Regulating Nucleolar Protein antibodyAnti-LYAR antibodyAnti-PNAS-5 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and LYAR knockout (KO) 293T cells, using [KO Validated] LYAR Rabbit polyclonal antibody (STJ11100776) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89712/358194/STJ11100776_1__10553.1713122510.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and LYAR knockout (KO) 293T cells, using [KO Validated] LYAR Rabbit polyclonal antibody (STJ11100776) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
