| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Leukotriene C4 synthase synthase (29-79 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LTC4S |
| Gene ID: | 4056 |
| Uniprot ID: | LTC4S_HUMAN |
| Immunogen Region: | 29-79 aa |
| Specificity: | This antibody detects endogenous levels of LTC4S at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human LTC4S at the amino acid range 29-79 |
| Post Translational Modifications | Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. |
| Function | Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. |
| Protein Name | Leukotriene C4 SynthaseLtc4 SynthaseGlutathione S-Transferase Ltc4Leukotriene-C(4 SynthaseLeukotriene-C4 Synthase |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142691Reactome: R-HSA-2142700Reactome: R-HSA-9026762Reactome: R-HSA-9026766 |
| Cellular Localisation | Nucleus Outer MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneNucleus Membrane |
| Alternative Antibody Names | Anti-Leukotriene C4 Synthase antibodyAnti-Ltc4 Synthase antibodyAnti-Glutathione S-Transferase Ltc4 antibodyAnti-Leukotriene-C(4 Synthase antibodyAnti-Leukotriene-C4 Synthase antibodyAnti-LTC4S antibody |
Information sourced from Uniprot.org
