Anti-LTA4H antibody (501-600) [S5MR] (STJ11102395)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal LTA4H (501-600) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LTA4H |
| Gene ID | 4048 |
| Uniprot ID | LKHA4_HUMAN |
| Immunogen Region | 501-600 |
| Immunogen Sequence | NEFLAQTLQRAPLPLGHIKR MQEVYNFNAINNSEIRFRWL RLCIQSKWEDAIPLALKMAT EQGRMKFTRPLFKDLAAFDK SHDQAVRTYQEHKASMHPVT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 501-600 of human LTA4H (P09960). |
Additional Info
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts. |
| Post Translational Modifications | Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity. |
| Function | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions. |
| Protein Name | Leukotriene A-4 HydrolaseLta-4 HydrolaseLeukotriene A(4 HydrolaseTripeptide Aminopeptidase Lta4h |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-6798695Reactome: R-HSA-9018676Reactome: R-HSA-9018681Reactome: R-HSA-9018896Reactome: R-HSA-9020265Reactome: R-HSA-9023661 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Leukotriene A-4 Hydrolase antibodyAnti-Lta-4 Hydrolase antibodyAnti-Leukotriene A(4 Hydrolase antibodyAnti-Tripeptide Aminopeptidase Lta4h antibodyAnti-LTA4H antibodyAnti-LTA4 antibody |
Information sourced from Uniprot.org