| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-LSD2/KDM1B/AOF1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S0MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KDM1B |
| Gene ID: |
221656 |
| Uniprot ID: |
KDM1B_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LSD2/KDM1B/AOF1 (NP_694587.3). |
| Immunogen Sequence: |
MATPRGRTKKKASFDHSPDS LPLRSSGRQAKKKATETTDE DEDGGSEKKYRKCEKAGCTA TCPVCFASASERCAKNGYTS RWYHLSCGEHFCNECFDHYY |
| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. |
| Protein Name | Lysine-Specific Histone Demethylase 2Flavin-Containing Amine Oxidase Domain-Containing Protein 1Lysine-Specific Histone Demethylase 1b |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5689603Reactome: R-HSA-9029569 |
| Cellular Localisation | NucleusChromosomeFound In Actively Rnapolii-Transcribed Gene Bodies |
| Alternative Antibody Names | Anti-Lysine-Specific Histone Demethylase 2 antibodyAnti-Flavin-Containing Amine Oxidase Domain-Containing Protein 1 antibodyAnti-Lysine-Specific Histone Demethylase 1b antibodyAnti-KDM1B antibodyAnti-AOF1 antibodyAnti-C6orf193 antibodyAnti-LSD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
