| Short Description : | Rabbit polyclonal LRRK1 (10-90) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRRK1 |
| Gene ID: | 79705 |
| Uniprot ID: | LRRK1_HUMAN |
| Immunogen Region: | 10-90 |
| Immunogen Sequence: | SMYWCVGPEESAVCPERAME TLNGAGDTGGKPSTRGGDPA ARSRRTEGIRAAYRRGDRGG ARDLLEEACDQCASQLEKGQ L |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-90 of human LRRK1 (NP_078928.3). |
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is inhibited in its dimeric state. Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Thr-1061, Ser-1064, Ser-1074 and Thr-1075. Phosphorylation at these Ser-1064, Ser-1074 and Thr-1075 activates the kinase activity of LRRK1 to phosphorylate RAB7A. |
| Function | Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. |
| Protein Name | Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 antibodyAnti-LRRK1 antibodyAnti-KIAA1790 antibody |
Information sourced from Uniprot.org
