| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Low-Density Lipoprotein Receptor-Related Protein 4 (1621-1720) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LRP4 |
| Gene ID: |
4038 |
| Uniprot ID: |
LRP4_HUMAN |
| Immunogen Region: |
1621-1720 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1621-1720 of human LRP4 (NP_002325.2). |
| Immunogen Sequence: |
NGGCTHLCFARASDFVCACP DEPDSRPCSLVPGLVPPAPR ATGMSEKSPVLPNTPPTTLY SSTTRTRTSLEEVEGRCSER DARLGLCARSNDAVPAAPGE |
| Tissue Specificity | Expressed in bone.present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain. |
| Function | Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation. |
| Protein Name | Low-Density Lipoprotein Receptor-Related Protein 4Lrp-4Multiple Epidermal Growth Factor-Like Domains 7 |
| Database Links | Reactome: R-HSA-3000178 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Low-Density Lipoprotein Receptor-Related Protein 4 antibodyAnti-Lrp-4 antibodyAnti-Multiple Epidermal Growth Factor-Like Domains 7 antibodyAnti-LRP4 antibodyAnti-KIAA0816 antibodyAnti-LRP10 antibodyAnti-MEGF7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
