| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LPAR2 (250-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LPAR2Uniprot ID=LPAR2_HUMAN" |
| Immunogen Region: |
250-350 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human LPAR2 (NP_004711.2). |
| Immunogen Sequence: |
FVVCWTPGQVVLLLDGLGCE SCNVLAVEKYFLLLAEANSL VNAAVYSCRDAEMRRTFRRL LCCACLRQSTRESVHYTSSA QGGASTRIMLPENGHPLMDS T |
| Tissue Specificity | Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon. |
| Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. |
| Protein Name | Lysophosphatidic Acid Receptor 2Lpa Receptor 2Lpa-2Lysophosphatidic Acid Receptor Edg-4 |
| Cellular Localisation | Cell SurfaceCell MembraneMulti-Pass Membrane ProteinPrior To Lpa Treatment Found Predominantly At The Cell Surface But In The Presence Of Lpa Colocalizes With Rala In The Endocytic Vesicles |
| Alternative Antibody Names | Anti-Lysophosphatidic Acid Receptor 2 antibodyAnti-Lpa Receptor 2 antibodyAnti-Lpa-2 antibodyAnti-Lysophosphatidic Acid Receptor Edg-4 antibodyAnti-LPAR2 antibodyAnti-EDG4 antibodyAnti-LPA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
