Anti-LOXL1 antibody (95-370) (STJ112229)

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STJ112229
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LOXL1
Gene ID: 4016
Uniprot ID: LOXL1_HUMAN
Immunogen Region: 95-370
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 95-370 of human LOXL1 (NP_005567.2).
Immunogen Sequence: RQAPSLPLPGRVGSDTVRGQ ARHPFGFGQVPDNWREVAVG DSTGMARARTSVSQQRHGGS ASSVSASAFASTYRQQPSYP QQFPYPQAPFVSQYENYDPA SRTYDQGFVYYRPAGGGVGA GAAAVASAGVIYPYQPRARY EEYGGGEELPEYPPQGFYPA PERPYVPPPPPPPDGLDRRY SHSLYSEGTPGFEQAYPDPG PEAAQAHGGDPRLGWYPPYA NPPPEAYGPPRALEPPYLP
Tissue Specificity Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina.
Post Translational Modifications The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytic proccessing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation.
Function Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age.
Protein Name Lysyl Oxidase Homolog 1
Lysyl Oxidase-Like Protein 1
Lol
Database Links Reactome: R-HSA-1566948
Reactome: R-HSA-2243919
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Lysyl Oxidase Homolog 1 antibody
Anti-Lysyl Oxidase-Like Protein 1 antibody
Anti-Lol antibody
Anti-LOXL1 antibody
Anti-LOXL antibody

Information sourced from Uniprot.org