| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LOXL1 |
| Gene ID: |
4016 |
| Uniprot ID: |
LOXL1_HUMAN |
| Immunogen Region: |
95-370 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 95-370 of human LOXL1 (NP_005567.2). |
| Immunogen Sequence: |
RQAPSLPLPGRVGSDTVRGQ ARHPFGFGQVPDNWREVAVG DSTGMARARTSVSQQRHGGS ASSVSASAFASTYRQQPSYP QQFPYPQAPFVSQYENYDPA SRTYDQGFVYYRPAGGGVGA GAAAVASAGVIYPYQPRARY EEYGGGEELPEYPPQGFYPA PERPYVPPPPPPPDGLDRRY SHSLYSEGTPGFEQAYPDPG PEAAQAHGGDPRLGWYPPYA NPPPEAYGPPRALEPPYLP |
| Tissue Specificity | Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina. |
| Post Translational Modifications | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytic proccessing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation. |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age. |
| Protein Name | Lysyl Oxidase Homolog 1Lysyl Oxidase-Like Protein 1Lol |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-2243919 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Lysyl Oxidase Homolog 1 antibodyAnti-Lysyl Oxidase-Like Protein 1 antibodyAnti-Lol antibodyAnti-LOXL1 antibodyAnti-LOXL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
