| Tissue Specificity | Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina. |
| Post Translational Modifications | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytic proccessing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation. |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age. |
| Protein Name | Lysyl Oxidase Homolog 1Lysyl Oxidase-Like Protein 1Lol |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-2243919 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Lysyl Oxidase Homolog 1 antibodyAnti-Lysyl Oxidase-Like Protein 1 antibodyAnti-Lol antibodyAnti-LOXL1 antibodyAnti-LOXL antibody |
Information sourced from Uniprot.org
