| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LONP2 |
| Gene ID: | 83752 |
| Uniprot ID: | LONP2_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LONP2 (NP_113678.2). |
| Immunogen Sequence: | MSSVSPIQIPSRLPLLLTHE GVLLPGSTMRTSVDSARNLQ LVRSRLLKGTSLQSTILGVI PNTPDPASDAQDLPPLHRIG TAALAVQVVGSNWPKPHYTL LITGLCRFQIVQVLKEKPYP IAEVEQLDRLEEFPNTCKMR EELGELSEQFYKYAVQLVEM LDMSVPAVAKLRRLLDSLPR EALPDILTSIIRTSNKEKLQ ILDAVSLEERFKMTIPLLVR QIEGLKLLQKTRKPKQDDD |
| Tissue Specificity | Widely expressed, with high levels in the liver, kidney and pancreas. |
| Function | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. |
| Protein Name | Lon Protease Homolog 2 - PeroxisomalLon Protease-Like Protein 2Lon Protease 2Peroxisomal Lon ProteasePlon |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome Matrix |
| Alternative Antibody Names | Anti-Lon Protease Homolog 2 - Peroxisomal antibodyAnti-Lon Protease-Like Protein 2 antibodyAnti-Lon Protease 2 antibodyAnti-Peroxisomal Lon Protease antibodyAnti-Plon antibodyAnti-LONP2 antibodyAnti-LONP antibody |
Information sourced from Uniprot.org