| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LMAN1 |
| Gene ID: | 3998 |
| Uniprot ID: | LMAN1_HUMAN |
| Immunogen Region: | 270-480 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-480 of human LMAN1 (NP_005561.1). |
| Immunogen Sequence: | PGKEPPTPDKEISEKEKEKY QEEFEHFQQELDKKKEEFQK GHPDLQGQPAEEIFESVGDR ELRQVFEGQNRIHLEIKQLN RQLDMILDEQRRYVSSLTEE ISKRGAGMPGQHGQITQQEL DTVVKTQHEILRQVNEMKNS MSETVRLVSGMQHPGSAGGV YETTQHFIDIKEHLHIVKRD IDNLVQRNMPSNEKPKCPEL PPFPSCLSTVH |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | The N-terminal may be partly blocked. |
| Function | Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. |
| Protein Name | Protein Ergic-53Er-Golgi Intermediate Compartment 53 Kda ProteinGp58Intracellular Mannose-Specific Lectin Mr60Lectin Mannose-Binding 1 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-948021 |
| Cellular Localisation | Endoplasmic Reticulum-Golgi Intermediate Compartment MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Protein Ergic-53 antibodyAnti-Er-Golgi Intermediate Compartment 53 Kda Protein antibodyAnti-Gp58 antibodyAnti-Intracellular Mannose-Specific Lectin Mr60 antibodyAnti-Lectin Mannose-Binding 1 antibodyAnti-LMAN1 antibodyAnti-ERGIC53 antibodyAnti-F5F8D antibody |
Information sourced from Uniprot.org